cardiac myocyte การใช้

• These changes impair mitochondrial energy production and drive cardiac myocyte apoptosis.
• The "'diad "'is a structure in the cardiac myocyte located at the sarcomere Z-line.
• Like skeletal myocytes ( and axons for that matter ), in the resting state a given cardiac myocyte has a negative membrane potential.
• Cardiac myocyte renewal has been found to occur in normal adult humans, and at a higher rate in adults following acute heart injury such as infarction.
• KCNE4 strongly inhibits the KCNQ1 potassium channel, which is known to play important roles in human cardiac myocyte repolarization, and in multiple epithelial cell types.
• The VDAC is an important constituent in apoptotic signaling and oxidative stress, most notably as part of the mitochondrial death pathway and cardiac myocyte apoptosis signaling.
• The SOD1 enzyme is an important constituent in apoptotic signaling and oxidative stress, most notably as part of the mitochondrial death pathway and cardiac myocyte apoptosis signaling.
• The SOD2 enzyme is an important constituent in apoptotic signaling and oxidative stress, most notably as part of the mitochondrial death pathway and cardiac myocyte apoptosis signaling.
• The SLC25A31 enzyme is an important constituent in apoptotic signaling and oxidative stress, most notably as part of the mitochondrial death pathway and cardiac myocyte apoptosis signaling.
• The SLC25A5 enzyme is an important constituent in apoptotic signaling and oxidative stress, most notably as part of the mitochondrial death pathway and cardiac myocyte apoptosis signaling.
• Thus, activators of PKA, such as the beta-adrenergic agonist epinephrine ( released by sympathetic stimulation ), may enhance the rate of cardiac myocyte relaxation.
• The Endonuclase G enzyme is an important constituent in apoptotic signaling and oxidative stress, most notably as part of the mitochondrial death pathway and cardiac myocyte apoptosis signaling.
• Poly ( ADP-ribose ) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD + depletion and reduced Sirt2a deacetylase activity.
• Hsp20 also serves a significant role in preventing platelet aggregation, cardiac myocyte function and prevention of apoptosis after ischemic injury, and skeletal muscle function and muscle insulin response.
• Other results of Cripto disruption include the lack of posterior structures . and a block on the differentiation of cardiac myocyte, . both of which lead to embryonic death.
• In the heart Foxp1 has 3 vital roles, these include the regulation of cardiac myocyte maturation and proliferation, outflow tract separation of the pulmonary artery and aorta, and expression of knockout embryos display severe defects in cardiac morphogenesis.
• Histologically, " Mybpc3 "-targeted knock-out hearts display structural rearrangements with cardiac myocyte disarray and increased interstitial fibrosis similar to patients with hypertrophic cardiomyopathy, without obvious alterations in shape or size of single cardiac myocytes.
• As PPAR? activation triggers the expression of genes involved in lipid metabolism ( M-CPTI I and MCAD ), treating the mice with pirinixic acid may improve cardiac myocyte energy supply by increasing mitochondrial fatty acid ?-oxidation to prevent severe cardiac dysfunction as a result of lipid accumulation.
• While at Brigham and Women s Hospital and Harvard Medical School he worked with Thomas Woodward Smith, MD, Chief of Cardiovascular Medicine and Professor of Medicine, Harvard Medical School and Ralph A Kelly, MD . At that time he worked as a part of a team to tease out the intracellular cell signaling pathways in response to a paracrine growth factor Neuregulin-1 in the cardiac myocyte.